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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase.
Zeng, Jingkun; Weissmann, Florian; Bertolin, Agustina P; Posse, Viktor; Canal, Berta; Ulferts, Rachel; Wu, Mary; Harvey, Ruth; Hussain, Saira; Milligan, Jennifer C; Roustan, Chloe; Borg, Annabel; McCoy, Laura; Drury, Lucy S; Kjaer, Svend; McCauley, John; Howell, Michael; Beale, Rupert; Diffley, John F X.
Afiliação
  • Zeng J; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Bertolin AP; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Posse V; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Wu M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Harvey R; World Influenza Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Hussain S; World Influenza Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Milligan JC; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Roustan C; Structural Biology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Borg A; Structural Biology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • McCoy L; Division of Infection and Immunity, University College London, London WC1E 6BT, U.K.
  • Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Kjaer S; Structural Biology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • McCauley J; World Influenza Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Howell M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Biochem J ; 478(13): 2405-2423, 2021 07 16.
Article em En | MEDLINE | ID: mdl-34198322

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Proteínas não Estruturais Virais / RNA Helicases / Avaliação Pré-Clínica de Medicamentos / Bibliotecas de Moléculas Pequenas / SARS-CoV-2 Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: Biochem J Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Proteínas não Estruturais Virais / RNA Helicases / Avaliação Pré-Clínica de Medicamentos / Bibliotecas de Moléculas Pequenas / SARS-CoV-2 Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: Biochem J Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido