Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes.
Nanomedicine
; 37: 102439, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34256063
ABSTRACT
Depletion of coenzyme Q (CoQ) is associated with disease, ranging from myopathy to heart failure. To induce a CoQ deficit, C2C12 myotubes were incubated with high dose simvastatin. This resulted in a concentration-dependent inhibition of cell viability. Simvastatin-induced effects were prevented by co-incubation with mevalonic acid. When myotubes were incubated with 60 µM simvastatin, mitochondrial CoQ content decreased while co-incubation with CoQ nanodisks (ND) increased mitochondrial CoQ levels and improved cell viability. Incubation of myotubes with simvastatin also led to a reduction in oxygen consumption rate (OCR). When myotubes were co-incubated with simvastatin and CoQ ND, the decline in OCR was ameliorated. The data indicate that CoQ ND represent a water soluble vehicle capable of delivering CoQ to cultured myotubes. Thus, these biocompatible nanoparticles have the potential to bypass poor CoQ oral bioavailability as a treatment option for individuals with severe CoQ deficiency syndromes and/or aging-related CoQ depletion.
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MEDLINE
Assunto principal:
Ataxia
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Ubiquinona
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Debilidade Muscular
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Sinvastatina
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Doenças Mitocondriais
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Nanocompostos
Idioma:
En
Revista:
Nanomedicine
Ano de publicação:
2021
Tipo de documento:
Article