Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model.
Reprod Sci
; 29(2): 578-585, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34542890
ABSTRACT
Preeclampsia (PE) is a pregnancy complication commonly characterized by high blood pressure. Although it is generally believed that the placenta is the root cause of PE, the exact pathogenesis is unknown; consequently, there is no standard clinical treatment. Therefore, it is necessary to explore new therapeutic drugs. Several studies have reported that pyrroloquinoline quinone (PQQ) exhibits anti-inflammatory and antioxidative effects. The purpose of this study was to investigate the protective effect of PQQ diet supplementation on PE-like rat models. L-NAME induced PE-like model rats were intraperitonially administrated with PQQ. The results showed that PQQ significantly improved clinical manifestations and pregnancy outcomes of PE-like rats. The levels of related inflammatory and antioxidant markers were also significantly reversed. A mechanism study showed that PQQ may achieve the above therapeutic effects by inhibiting NF-κB and promoting Nrf2 antioxidant pathways. In conclusion, we showed the protective effect of PQQ on PE-like model rats, by improving anti-inflammation and antioxidation effect through the NF-κB-Nrf2 pathway.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
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NG-Nitroarginina Metil Éster
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Cofator PQQ
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Anti-Inflamatórios
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Antioxidantes
Idioma:
En
Revista:
Reprod Sci
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China