7DG, 7-desacetoxy-6,7-dehydrogedunin; ADRA2B, α-2B adrenergic receptor; AIM, absent in melanoma; ASC, associated speck-like protein; Ac-FLTD-CMK, acetyl-FLTD-chloromethylketone; BMDM, bone marrow-derived macrophages; CARD, caspase activation; CD, Crohn's disease; CTM, Chinese traditional medicine; CTSG, cathepsin G; Caspase; DAMP, damage-associated molecular pattern; DFNA5, deafness autosomal dominant 5; DFNB59, deafness autosomal recessive type 59; DKD, diabetic kidney disease; DMF, dimethyl fumarate; Damage-associated molecular patterns (DAMPs); ELANE, neutrophil expressed elastase; ESCRT, endosomal sorting complexes required for transport; FADD, FAS-associated death domain; FDA, U.S. Food and Drug Administration; FIIND, function to find domain; FMF, familial Mediterranean fever; GI, gastrointestinal; GPX, glutathione peroxidase; Gasdermin; GsdmA/B/C/D/E, gasdermin A/B/C/D/E; HAMP, homeostasis altering molecular pattern; HIN, hematopoietic expression, interferon-inducible nature, and nuclear localization; HIV, human immunodeficiency virus; HMGB1, high mobility group protein B1; IBD, inflammatory bowel disease; IFN, interferon; ITPR1, inositol 1,4,5-trisphosphate receptor type 1; Inflammasome; Inflammation; LPS, lipopolysaccharide; LRR, leucine-rich repeat; MAP3K7, mitogen-activated protein kinase kinase kinase 7; MCC950, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide; NAIP, NLR family apoptosis inhibitory protein; NBD, nucleotide-binding domain; NEK7, NIMA-related kinase 7; NET, neutrophil extracellular trap; NIK, NF-κB inducing kinase; NLR, NOD-like receptor; NLRP, NLR family pyrin domain containing; NSAID, non-steroidal anti-inflammatory drug; NSCLC, non-small cell lung cancer; NSP, neutrophil specific serine protease; PAMP, pathogen-associated molecular pattern; PKA, protein kinase A; PKN1/2, protein kinase1/2; PKR, protein kinase-R; PRR, pattern recognition receptors; PYD, pyrin domain; Pathogen-associated molecular patterns (PAMPs); Pyroptosis; ROS, reactive oxygen species; STING, stimulator of interferon genes; Sepsis; TLR, Toll-like receptor; UC, ulcerative colitis; cAMP, cyclic adenosine monophosphate; cGAS, cyclic GMP­AMP synthase; mtDNA, mitochondrial DNA