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Limonoids and unsaturated fatty acids present in Melia toosendan increase ceramide production in keratinocytes.
Kawasaki, Akiko; Hashimoto, Hiroshi; Shimotoyodome, Yoshie; Ito, Shotaro; Ishikawa, Junko; Sugai, Yoshiya; Fujimori, Taketoshi.
Afiliação
  • Kawasaki A; Biological Science Research, Kao Corporation, Akabane 2606, Haga-Gun, Ichikai-Machi, Tochigi 321-3497, Japan. Electronic address: kawasaki.akiko@kao.com.
  • Hashimoto H; Biological Science Research, Kao Corporation, Akabane 2606, Haga-Gun, Ichikai-Machi, Tochigi 321-3497, Japan.
  • Shimotoyodome Y; Biological Science Research, Kao Corporation, 2-1-3, Bunka, Sumida, Tokyo 131-8501, Japan.
  • Ito S; Personal Healthcare Research, Kao Corporation, 2-1-3, Bunka, Sumida, Tokyo 131-8501, Japan.
  • Ishikawa J; Biological Science Research, Kao Corporation, Akabane 2606, Haga-Gun, Ichikai-Machi, Tochigi 321-3497, Japan.
  • Sugai Y; Biological Science Research, Kao Corporation, Akabane 2606, Haga-Gun, Ichikai-Machi, Tochigi 321-3497, Japan.
  • Fujimori T; Biological Science Research, Kao Corporation, Akabane 2606, Haga-Gun, Ichikai-Machi, Tochigi 321-3497, Japan.
Fitoterapia ; 155: 105058, 2021 Nov.
Article em En | MEDLINE | ID: mdl-34637887
The skin barrier prevents moisture evaporation and the entry of foreign substances such as allergens. Ceramides are one of the most important factors for maintaining skin barrier function. Melia toosendan is a plant of the Meliaceae family, and its fruit extracts have been used in Traditional Chinese Medicine as analgesics and anthelmintics; however, its ability to increase ceramide levels has not been reported. In this study, we screened for compounds present in M. toosendan fruit extracts that increase ceramide levels in the skin. We fractionated the extracts based on their activity to identify the active components. Nimbolinins, limonoids such as toosendanin, and hydroxylated unsaturated fatty acids were found to be the major active components. The structure-activity relationship of toosendanin derivatives indicated that the sites around R4 and R5 contributed to the activity. To the best of our knowledge, this is the first report showing that limonoids promote ceramide production in skin cells. Therefore, M. toosendan fruit extracts may be used to develop products for improving the skin barrier function.
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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Queratinócitos / Ceramidas / Melia / Limoninas / Ácidos Graxos Insaturados Tipo de estudo: Prognostic_studies País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Queratinócitos / Ceramidas / Melia / Limoninas / Ácidos Graxos Insaturados Tipo de estudo: Prognostic_studies País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2021 Tipo de documento: Article