Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia.
Int J Mol Sci
; 22(19)2021 Oct 06.
Article
em En
| MEDLINE
| ID: mdl-34639136
ABSTRACT
BACKGROUND:
α-cyclodextrin (α-CD) is one of the dietary fibers that may have a beneficial effect on cholesterol and/or glucose metabolism, but its efficacy and mode of action remain unclear.METHODS:
In the present study, we examined the anti-hyperglycemic effect of α-CD after oral loading of glucose and liquid meal in mice.RESULTS:
Administration of 2 g/kg α-CD suppressed hyperglycemia after glucose loading, which was associated with increased glucagon-like peptide 1 (GLP-1) secretion and enhanced hepatic glucose sequestration. By contrast, 1 g/kg α-CD similarly suppressed hyperglycemia, but without increasing secretions of GLP-1 and insulin. Furthermore, oral α-CD administration disrupts lipid micelle formation through its inclusion of lecithin in the gut luminal fluid. Importantly, prior inclusion of α-CD with lecithin in vitro nullified the anti-hyperglycemic effect of α-CD in vivo, which was associated with increased intestinal mRNA expressions of SREBP2-target genes (Ldlr, Hmgcr, Pcsk9, and Srebp2).CONCLUSIONS:
α-CD elicits its anti-hyperglycemic effect after glucose loading by inducing lecithin inclusion in the gut lumen and activating SREBP2, which is known to induce cholecystokinin secretion to suppress hepatic glucose production via a gut/brain/liver axis.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Período Pós-Prandial
/
Canais de Potássio Corretores do Fluxo de Internalização
/
Trato Gastrointestinal
/
Alfa-Ciclodextrinas
/
Proteína de Ligação a Elemento Regulador de Esterol 2
/
Lecitinas
/
Hiperglicemia
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão