Integrated Network Pharmacology Analysis and <i>In Vitro</i> Validation Revealed the Potential Active Components and Underlying Mechanistic Pathways of Herba Patriniae in Colorectal Cancer.

Yang, Huihai; Cheung, Man-Kit; Yue, Grace Gar-Lee; Leung, Ping-Chung; Wong, Chun-Kwok; Lau, Clara Bik-San

Integrated Network Pharmacology Analysis and In Vitro Validation Revealed the Potential Active Components and Underlying Mechanistic Pathways of Herba Patriniae in Colorectal Cancer.

Yang, Huihai; Cheung, Man-Kit; Yue, Grace Gar-Lee; Leung, Ping-Chung; Wong, Chun-Kwok; Lau, Clara Bik-San.

Afiliação

Yang H; Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Cheung MK; Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Yue GG; Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Leung PC; Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Wong CK; Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Lau CB; Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Molecules ; 26(19)2021 Oct 05.

Article em En | MEDLINE | ID: mdl-34641576

Assuntos

Neoplasias Colorretais/tratamento farmacológico; Medicamentos de Ervas Chinesas/química; Medicamentos de Ervas Chinesas/farmacologia; Extratos Vegetais/química; Extratos Vegetais/farmacologia; Transdução de Sinais/efeitos dos fármacos; Adenocarcinoma/tratamento farmacológico; Antineoplásicos/química; Antineoplásicos/farmacologia; Movimento Celular/efeitos dos fármacos; Dipeptídeos/farmacologia; Descoberta de Drogas/métodos; Receptores ErbB/metabolismo; Proteína Forkhead Box O1/metabolismo; Regulação Neoplásica da Expressão Gênica; Células HCT116; Humanos; Medicina Tradicional Chinesa; Patrinia/química; Plantas Medicinais/química

Palavras-chave

CRC; ErbB signaling pathway; FoxO signaling pathway; Herba Patriniae; Patrinia heterophylla; colorectal cancer; network pharmacology

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas / Plantas_medicinales Assunto principal: Medicamentos de Ervas Chinesas / Extratos Vegetais / Neoplasias Colorretais / Transdução de Sinais Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Molecules Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Hong Kong

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