Neuromedin B receptor stimulation of Cav3.2 T-type Ca<sup>2+</sup> channels in primary sensory neurons mediates peripheral pain hypersensitivity.

Zhang, Yuan; Qian, Zhiyuan; Jiang, Dongsheng; Sun, Yufang; Gao, Shangshang; Jiang, Xinghong; Wang, Hua; Tao, Jin

Neuromedin B receptor stimulation of Cav3.2 T-type Ca²⁺ channels in primary sensory neurons mediates peripheral pain hypersensitivity.

Zhang, Yuan; Qian, Zhiyuan; Jiang, Dongsheng; Sun, Yufang; Gao, Shangshang; Jiang, Xinghong; Wang, Hua; Tao, Jin.

Afiliação

Zhang Y; Department of Geriatrics & Institute of Neuroscience, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Qian Z; Department of Physiology and Neurobiology & Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou 215123, China.
Jiang D; Department of Geriatrics & Institute of Neuroscience, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Sun Y; Comprehensive Pneumology Center, Helmholtz Zentrum München, Munich 81377, Germany.
Gao S; Department of Physiology and Neurobiology & Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou 215123, China.
Jiang X; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou 215123, China.
Wang H; Department of Physiology and Neurobiology & Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou 215123, China.
Tao J; Department of Physiology and Neurobiology & Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou 215123, China.

Theranostics ; 11(19): 9342-9357, 2021.

Article em En | MEDLINE | ID: mdl-34646374

Assuntos

Canais de Cálcio Tipo T/metabolismo; Dor/metabolismo; Receptores da Bombesina/metabolismo; Potenciais de Ação; Animais; Canais de Cálcio Tipo T/fisiologia; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Feminino; Adjuvante de Freund/farmacologia; Gânglios Espinais/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos ICR; Neurocinina B/análogos & derivados; Neurocinina B/metabolismo; Dor/fisiopatologia; Receptores da Bombesina/fisiologia; Receptores Acoplados a Proteínas G/metabolismo; Células Receptoras Sensoriais/metabolismo; Células Receptoras Sensoriais/fisiologia; Transdução de Sinais/efeitos dos fármacos; Gânglio Trigeminal/citologia; Gânglio Trigeminal/metabolismo

Palavras-chave

T-type Ca2+ channel; neuromedin B receptor; protein kinase A; trigeminal ganglion neurons

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Receptores da Bombesina / Canais de Cálcio Tipo T Idioma: En Revista: Theranostics Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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