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Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates.
El Omari, Nasreddine; Bakrim, Saad; Bakha, Mohamed; Lorenzo, José M; Rebezov, Maksim; Shariati, Mohammad Ali; Aboulaghras, Sara; Balahbib, Abdelaali; Khayrullin, Mars; Bouyahya, Abdelhakim.
Afiliação
  • El Omari N; Laboratory of Histology, Embryology, and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat P.O. Box 1014, Morocco.
  • Bakrim S; Molecular Engineering, Valorization and Environment Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir 80000, Morocco.
  • Bakha M; Biotechnology and Applied Microbiology Team, Department of Biology, Faculty of Science, Abdelmalek Essaadi University, Tetouan 93002, Morocco.
  • Lorenzo JM; Centro Tecnológico de la Carne de Galicia, Rúa Galicia No. 4, Parque Tecnológico de Galicia, San Cibrao das Viñas, 32900 Ourense, Spain.
  • Rebezov M; Área de Tecnología de los Alimentos, Facultad de Ciencias de Ourense, Universidad de Vigo, 32004 Ourense, Spain.
  • Shariati MA; V. M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, 26 Talalikhina St., 109316 Moscow, Russia.
  • Aboulaghras S; Department of Scientific Research, School of Agricultural Sciences, Liaocheng University, 34 Wenhua Road, Liaocheng 252000, China.
  • Balahbib A; Department of Scientific Research, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), 73, Zemlyanoy Val St., 109004 Moscow, Russia.
  • Khayrullin M; Department of Scientific Research, School of Agricultural Sciences, Liaocheng University, 34 Wenhua Road, Liaocheng 252000, China.
  • Bouyahya A; Department of Scientific Research, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), 73, Zemlyanoy Val St., 109004 Moscow, Russia.
Nutrients ; 13(11)2021 Oct 22.
Article em En | MEDLINE | ID: mdl-34835969
ABSTRACT
Cancer is one of the most complex and systemic diseases affecting the health of mankind, causing major deaths with a significant increase. This pathology is caused by several risk factors, of which genetic disturbances constitute the major elements, which not only initiate tumor transformation but also epigenetic disturbances which are linked to it and which can induce transcriptional instability. Indeed, the involvement of epigenetic disturbances in cancer has been the subject of correlations today, in addition to the use of drugs that operate specifically on different epigenetic pathways. Natural molecules, especially those isolated from medicinal plants, have shown anticancer effects linked to mechanisms of action. The objective of this review is to explore the anticancer effects of alkaloids, terpenoids, quinones, and isothiocyanates.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinonas / Terpenos / Produtos Biológicos / Isotiocianatos / Epigênese Genética / Alcaloides / Neoplasias Tipo de estudo: Risk_factors_studies Idioma: En Revista: Nutrients Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Marrocos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinonas / Terpenos / Produtos Biológicos / Isotiocianatos / Epigênese Genética / Alcaloides / Neoplasias Tipo de estudo: Risk_factors_studies Idioma: En Revista: Nutrients Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Marrocos