Stimulatory effect of acetylcholine on immunoreactive corticotropin-releasing factor release from the rat hypothalamus in vitro.
Life Sci
; 40(7): 673-7, 1987 Feb 16.
Article
em En
| MEDLINE
| ID: mdl-3492648
ABSTRACT
Effects of acetylcholine (Ach) and gamma-aminobutyric acid (GABA) on immunoreactive corticotropin-releasing factor (CRF) release from the rat hypothalamus were examined using a rat hypothalamic perifusion system and a rat CRF RIA in vitro. Ach stimulated CRF release in a dose-dependent manner (1 pM-1 nM). One nM Ach-induced CRF release was inhibited by atropine in a dose-dependent manner (1-100 nM), but was inhibited by only a high concentration (100 nM) of hexamethonium. In addition, such Ach-induced CRF release was inhibited by norepinephrine. GABA did not influence basal CRF release. These results suggest that Ach stimulates CRF release mainly through muscarinic receptors at least under our conditions.
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Base de dados:
MEDLINE
Medicinas Complementares:
Homeopatia
Assunto principal:
Hormônio Liberador da Corticotropina
/
Acetilcolina
/
Hipotálamo
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1987
Tipo de documento:
Article