Antiproliferative Effects of <i>Artabotrys odoratissimus</i> Fruit Extract and its Bioactive Fraction through Upregulation of p53/Î³H2AX Signals and G2/M Phase Arrest in MIA PaCa-2 Cells.

Pargi, Meghana; Jain Raviraj, Sandeep Kumar; Narayanappa, Prashanth; Urumarudappa, Santhosh Kumar J; Malleshappa, Pallavi; Malleshappa, Kumaraswamy Honnenahally

Antiproliferative Effects of Artabotrys odoratissimus Fruit Extract and its Bioactive Fraction through Upregulation of p53/Î³H2AX Signals and G2/M Phase Arrest in MIA PaCa-2 Cells.

Pargi, Meghana; Jain Raviraj, Sandeep Kumar; Narayanappa, Prashanth; Urumarudappa, Santhosh Kumar J; Malleshappa, Pallavi; Malleshappa, Kumaraswamy Honnenahally.

Afiliação

Pargi M; Department of Post Graduate Studies and Research in Biotechnology, Kuvempu University, Shankaraghatta 577451, Karnataka, India.
Jain Raviraj SK; Department of Post Graduate Studies and Research in Biotechnology, Kuvempu University, Shankaraghatta 577451, Karnataka, India.
Narayanappa P; Department of Post Graduate Studies and Research in Biotechnology, Kuvempu University, Shankaraghatta 577451, Karnataka, India.
Urumarudappa SKJ; Research Unit of DNA Barcoding of Thai Medicinal Plants, Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Malleshappa P; Postgraduate Department of Studies and Research in Biotechnology, Molecular Biomedicine Laboratory, Sahyadri Science College, Kuvempu University, Shimoga 577203, Karnataka, India.
Malleshappa KH; Department of Post Graduate Studies and Research in Biotechnology, Kuvempu University, Shankaraghatta 577451, Karnataka, India.

Anticancer Agents Med Chem ; 22(17): 2998-3008, 2022.

Article em En | MEDLINE | ID: mdl-35105296

Assuntos

Annonaceae; Frutas; Annonaceae/metabolismo; Antioxidantes/farmacologia; Apoptose; Pontos de Checagem do Ciclo Celular; Divisão Celular; Linhagem Celular Tumoral; Frutas/química; Humanos; Extratos Vegetais/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Regulação para Cima

Palavras-chave

Artabotrys odoratissimus; DNA damage; ROS; bioactive; oxidative stress; pancreatic cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Annonaceae / Frutas Idioma: En Revista: Anticancer Agents Med Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia

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