Delivery of acetogenin-enriched Annona muricata Linn leaf extract by folic acid-conjugated and triphenylphosphonium-conjugated poly(glycerol adipate) nanoparticles to enhance toxicity against ovarian cancer cells.

Damrongrak, Kanokporn; Kloysawat, Kiattiphant; Bunsupa, Somnuk; Sakchasri, Krisada; Wongrakpanich, Amaraporn; Taresco, Vincenzo; Cuzzucoli Crucitti, Valentina; Garnett, Martin C; Suksiriworapong, Jiraphong

Damrongrak, Kanokporn; Kloysawat, Kiattiphant; Bunsupa, Somnuk; Sakchasri, Krisada; Wongrakpanich, Amaraporn; Taresco, Vincenzo; Cuzzucoli Crucitti, Valentina; Garnett, Martin C; Suksiriworapong, Jiraphong.

Afiliação

Damrongrak K; Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Kloysawat K; Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Bunsupa S; Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Sakchasri K; Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Wongrakpanich A; Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Taresco V; School of Chemistry, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Cuzzucoli Crucitti V; Centre for Additive Manufacturing and Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Garnett MC; School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Suksiriworapong J; Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand. Electronic address: jiraphong.suk@mahidol.edu.

Int J Pharm ; 618: 121636, 2022 Apr 25.

Article em En | MEDLINE | ID: mdl-35259439

Assuntos

Annona; Nanopartículas; Neoplasias Ovarianas; Humanos; Adipatos; Portadores de Fármacos; Ácido Fólico; Glicerol; Neoplasias Ovarianas/tratamento farmacológico; Extratos Vegetais; Polietilenoglicóis; Polímeros

Palavras-chave

(4-carboxybutyl)triphenylphosphonium bromide; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-(dimethylamino) pyridine; Annona muricata; Folic acid; Hoechst 33342; MitoTracker™ Deep Red FM; N,N'-dicyclohexylcarbodiimide; N-hydroxysuccinimide; Nanoparticles; Ovarian cancer; Poly(glycerol adipate); Triphenyl phosphonium; Tumor targeting; amine poly(ethylene glycol) carboxyl; cholesteryl hemisuccinate; coumarin-6; folic acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Annona / Nanopartículas Idioma: En Revista: Int J Pharm Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Tailândia

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