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Identification of the potential mechanism of Radix pueraria in colon cancer based on network pharmacology.
Li, Yi; Zhang, Chunli; Ma, Xiaohan; Yang, Liuqing; Ren, Huijun.
Afiliação
  • Li Y; Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, People's Republic of China.
  • Zhang C; Department of General Surgery, The People's Hospital of Zhengzhou, Henan, China.
  • Ma X; The Third Affiliated Hospital of Zhengzhou University, Henan, China.
  • Yang L; Fuwai Central China Cardiovascular Hospital, Henan, China.
  • Ren H; Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, People's Republic of China. huijunren_2021@126.com.
Sci Rep ; 12(1): 3765, 2022 03 08.
Article em En | MEDLINE | ID: mdl-35260672
Radix Puerariae (RP), a dry root of Pueraria lobata (Willd.) Ohwi, is used to treat a variety of diseases, including cancer. Several in vitro and in vivo studies have demonstrated the efficacy of RP in the treatment of colon cancer (CC). However, the biological mechanism of RP in the treatment of colon cancer remains unclear. In this study, the active component of RP and its potential molecular mechanism against CC were studied by network pharmacology and enrichment analysis. The methods adopted included screening active ingredients of Chinese medicine, predicting target genes of Chinese medicine and disease, constructing of a protein interaction network, and conducting GO and KEGG enrichment analysis. Finally, the results of network pharmacology were further validated by molecular docking experiments and cell experiments. Eight active constituents and 14 potential protein targets were screened from RP, including EGFR, JAK2 and SRC. The biological mechanism of RP against CC was analysed by studying the relationship between active components, targets, and enrichment pathways. These findings provide a basis for understanding the clinical application of RP in CC.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Assunto principal: Medicamentos de Ervas Chinesas / Neoplasias do Colo / Pueraria Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Assunto principal: Medicamentos de Ervas Chinesas / Neoplasias do Colo / Pueraria Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article