Echinocandins - structure, mechanism of action and use in antifungal therapy.
J Enzyme Inhib Med Chem
; 37(1): 876-894, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-35296203
ABSTRACT
With increasing number of immunocompromised patients as well as drug resistance in fungi, the risk of fatal fungal infections in humans increases as well. The action of echinocandins is based on the inhibition of ß-(1,3)-d-glucan synthesis that builds the fungal cell wall. Caspofungin, micafungin, anidulafungin and rezafungin are semi-synthetic cyclic lipopeptides. Their specific chemical structure possess a potential to obtain novel derivatives with better pharmacological properties resulting in more effective treatment, especially in infections caused by Candida and Aspergillus species. In this review we summarise information about echinocandins with closer look on their chemical structure, mechanism of action, drug resistance and usage in clinical practice. We also introduce actual trends in modification of this antifungals as well as new methods of their administration, and additional use in viral and bacterial infections.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Plantas_medicinales
Assunto principal:
Aspergillus
/
Candida
/
Desenho de Fármacos
/
Equinocandinas
/
Antifúngicos
Idioma:
En
Revista:
J Enzyme Inhib Med Chem
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Polônia