Glycyrrhizin alleviates sepsis-induced acute respiratory distress syndrome via suppressing of HMGB1/TLR9 pathways and neutrophils extracellular traps formation.

Gu, Jiarun; Ran, Xufei; Deng, Jin; Zhang, Anqiang; Peng, Guoxuan; Du, Juan; Wen, Dalin; Jiang, Baowei; Xia, Fei

Gu, Jiarun; Ran, Xufei; Deng, Jin; Zhang, Anqiang; Peng, Guoxuan; Du, Juan; Wen, Dalin; Jiang, Baowei; Xia, Fei.

Afiliação

Gu J; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou 550001, China. Electronic address: dr_gujiarun@163.com.
Ran X; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou 550001, China. Electronic address: 707550968@qq.com.
Deng J; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, China. Electronic address: gydengjin@yeah.net.
Zhang A; State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing 400010, China. Electronic address: zhanganqiang@126.com.
Peng G; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou 550001, China. Electronic address: 1319389583@qq.com.
Du J; State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing 400010, China. Electronic address: dujuan1982727@163.com.
Wen D; State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing 400010, China. Electronic address: 13452607810@163.com.
Jiang B; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou 550001, China. Electronic address: 1759635114@qq.com.
Xia F; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, China. Electronic address: dr_xiafei@gmc.edu.cn.

Int Immunopharmacol ; 108: 108730, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35354111

Assuntos

Armadilhas Extracelulares; Proteína HMGB1; Lesão Pulmonar; Síndrome do Desconforto Respiratório; Sepse; Animais; Modelos Animais de Doenças; Armadilhas Extracelulares/metabolismo; Ácido Glicirrízico/farmacologia; Ácido Glicirrízico/uso terapêutico; Proteína HMGB1/metabolismo; Pulmão/patologia; Lesão Pulmonar/patologia; Camundongos; Fator 88 de Diferenciação Mieloide/metabolismo; Neutrófilos/metabolismo; Síndrome do Desconforto Respiratório/tratamento farmacológico; Síndrome do Desconforto Respiratório/etiologia; Sepse/complicações; Sepse/tratamento farmacológico; Sepse/metabolismo; Receptor Toll-Like 9/metabolismo

Palavras-chave

Acute respiratory distress syndrome; Glycyrrhizin; HMGB1; Neutrophil extracellular traps; Sepsis

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Síndrome do Desconforto Respiratório / Sepse / Proteína HMGB1 / Lesão Pulmonar / Armadilhas Extracelulares Tipo de estudo: Etiology_studies Idioma: En Revista: Int Immunopharmacol Ano de publicação: 2022 Tipo de documento: Article

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