Treatment of end-stage peripheral artery disease by neuromodulation.
Clin Hemorheol Microcirc
; 81(4): 315-324, 2022.
Article
em En
| MEDLINE
| ID: mdl-35466931
ABSTRACT
BACKGROUND:
Neuromodulation is a therapeutic option to improve limb salvage in end-stage peripheral arterial disease (PAD), but there is no consensus on its indication for spinal cord stimulation (SCS) in PAD patients.OBJECTIVE:
The aim of this study was to present the outcome of end-stage PAD patients treated with SCS.METHODS:
This study is a retrospective analysis based on a local prospective registry. Neuromodulation was performed if there was 1) no revascularisation option, 2) no septicemia, 3) and Rutherford stage 4-6. The primary endpoint of the study was limb salvage. Secondary endpoints were reduction in pain or simply pain reduction pain (assessed using a visual anlog scale/VAS) and improvement in walking distance.RESULTS:
Limb salvage was reached in 30/34 patients (88%). Patients reported a significant reduction in pain on the 10-point VAS scale from baseline (medianâ=â7.5, IQRâ=â7-8) to follow-up at 2 years (medianâ=â0, IQR 0-2.75), pâ<â0.001. Walking distance also improved from preoperative (medianâ=â50 m, IQRâ=â20-50 m) to follow-up at 2 years (medianâ=â150 m, IQR 50-272 m), pâ<â0.001.RESULTS:
SCS implantation in patients with end-stage PAD can enable limb salvage in a high percentage of cases and increase mobility due to pain reduction. The role of microcirculation in these improvements needs to be investigated in further studies.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Estimulação Elétrica Nervosa Transcutânea
/
Doença Arterial Periférica
Tipo de estudo:
Observational_studies
Idioma:
En
Revista:
Clin Hemorheol Microcirc
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Alemanha