Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy.
Inflammopharmacology
; 30(4): 1335-1349, 2022 Aug.
Article
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| MEDLINE
| ID: mdl-35708797
Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition in the joints and surrounding tissues. We examined the effects of Taxifolin, a natural flavonoid mainly existing in vegetables and fruits, on MSU-induced gout. Pretreatment with Taxifolin significantly reduced IL-1ß, Caspase-1 and HMGB1 levels, upregulation of autophagy-related protein, LC3, as well as improved phagocytosis of macrophages. This study indicated that Taxifolin-attenuated inflammatory response in MSU-induced acute gout model by decreasing pro-inflammatory cytokine production and promoting the autophagy and phagocytic capacity of macrophages. Dietary supplementation with Taxifolin induces the autophagy and attenuated inflammatory response, which in consequence modulates acute gout. A preventive strategy combining dietary interventions with Taxifolin may offer a potential therapeutic alternative to pharmacological treatment to reduce inflammatory response to gout.
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Base de dados:
MEDLINE
Assunto principal:
Artrite Gotosa
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Gota
Idioma:
En
Revista:
Inflammopharmacology
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China