Hyaluronic acid-coated Bi:Cu2O: an H2S-responsive agent for colon cancer with targeted delivery and enhanced photothermal performance.
J Nanobiotechnology
; 20(1): 346, 2022 Jul 26.
Article
em En
| MEDLINE
| ID: mdl-35883134
ABSTRACT
BACKGROUND:
Endogenous hydrogen sulfide (H2S)-responsive theranostic agents have attracted extensive attention due to their specificity for colon cancer. However, the development of such agents with high enrichment in tumors and excellent photothermal performance remains challenging.RESULTS:
We prepared hyaluronic acid (HA)-coated Bi-doped cuprous oxide (BiCu2O@HA) via a one-pot method. The HA specifically targets colon cancer tumor cells to improve the enrichment of BiCu2O@HA at tumor sites, while the doped Bi both enhances the photothermal performance of the H2S-triggered Cu2O and serves as an agent for tumor imaging. The results in this work demonstrated that the BiCu2O@HA nanoparticles exhibit good biocompatibility, target colon cancer tumor cells, facilitate computed tomography imaging, and enhanced H2S-responsive photothermal therapy performance, resulting in an excellent therapeutic effect in colon cancer.CONCLUSIONS:
The novel BiCu2O@HA nanoparticles exhibit excellent tumor targeting and photothermal therapeutic effects, which provide new strategies and insights for colon cancer therapy.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo
/
Nanopartículas
Idioma:
En
Revista:
J Nanobiotechnology
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China