Polyphenols in Highland Barley Tea Inhibit the Production of Advanced Glycosylation End-Products and Alleviate the Skeletal Muscle Damage.
Mol Nutr Food Res
; 66(18): e2200225, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35894228
ABSTRACT
SCOPE Highland barley tea is a kind of caffeine-free cereal tea. Previous studies have shown that it is rich in polyphenol flavonoids. Here, the effect of Highland barley tea polyphenols (HBP) on the production of advanced glycosylation end-products and alleviate the skeletal muscle damage is systematically investigated. METHODS AND RESULTS:
HBP effectively inhibits the formation of AGEs in vitro, and 12 phenolic compounds are identified. In addition, d-galactose is used to construct a mouse senescence model and intervenes with different doses of HBP. It is found that high doses of HBP effectively inhibit AGEs in serum and flounder muscle species and increased muscle mass in flounder muscle; also, high doses of HBP increase the expression of the mitochondrial functional protein SIRT3 and decrease the expression of myasthenia-related proteins. Furthermore, cellular experiments show that AGEs can significantly increase oxidative stress in skeletal muscle.CONCLUSION:
These data indicate that the relationship between the biological activity and HBP properties is relevant since Highland barley can be a potential functional food to prevent AGEs-mediated skeletal muscle damage.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hordeum
/
Sirtuína 3
Idioma:
En
Revista:
Mol Nutr Food Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China