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Rationally designed Ru(II) metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer.
Tu, Le; Li, Chonglu; Liu, Chang; Bai, Suya; Yang, Jingfang; Zhang, Xian; Xu, Liying; Xiong, Xiaoxing; Sun, Yao.
Afiliação
  • Tu L; Department of Neurosurgery, Remin Hospital of Wuhan University, Wuhan 430079, P. R. China. xiaoxingxiong@whu.edu.cn.
  • Li C; Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. sunyaogbasp@ccnu.edu.cn.
  • Liu C; Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. sunyaogbasp@ccnu.edu.cn.
  • Bai S; Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. sunyaogbasp@ccnu.edu.cn.
  • Yang J; Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. sunyaogbasp@ccnu.edu.cn.
  • Zhang X; Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. sunyaogbasp@ccnu.edu.cn.
  • Xu L; Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. sunyaogbasp@ccnu.edu.cn.
  • Xiong X; Zhongnan Hospital of Wuhan University, Wuhan 430062, P. R. China. aying0923@foxmail.com.
  • Sun Y; Department of Neurosurgery, Remin Hospital of Wuhan University, Wuhan 430079, P. R. China. xiaoxingxiong@whu.edu.cn.
Chem Commun (Camb) ; 58(65): 9068-9071, 2022 Aug 11.
Article em En | MEDLINE | ID: mdl-35894452
Herein, we construct a series of Ru(II) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting apoptosis. These results open new possibilities for Ru(II) metallacycles in biomedicine.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rutênio / Complexos de Coordenação / Neoplasias / Antineoplásicos Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rutênio / Complexos de Coordenação / Neoplasias / Antineoplásicos Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2022 Tipo de documento: Article