Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its active ingredients under conditions of glycerol fatty acid ester as emulsifiers.

Ota, Misato; Maki, Yasuhito; Xu, Ling-Yu; Makino, Toshiaki

Ota, Misato; Maki, Yasuhito; Xu, Ling-Yu; Makino, Toshiaki.

Afiliação

Ota M; Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Aichi, 467-8603, Japan; Kuki Sangyo Co., Ltd., 11 Onoe-cho, Yokkaichi-shi, Mie, 510-0059, Japan. Electronic address: prota-misato@phar.nagoya-cu.ac.jp.
Maki Y; Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Aichi, 467-8603, Japan; Kuki Sangyo Co., Ltd., 11 Onoe-cho, Yokkaichi-shi, Mie, 510-0059, Japan. Electronic address: y_maki@kuki-info.co.jp.
Xu LY; Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Aichi, 467-8603, Japan. Electronic address: minaduki1202@126.com.
Makino T; Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Aichi, 467-8603, Japan. Electronic address: makino@phar.nagoya-cu.ac.jp.

J Ethnopharmacol ; 298: 115625, 2022 Nov 15.

Article em En | MEDLINE | ID: mdl-35970315

Assuntos

Distúrbios do Início e da Manutenção do Sono; Valeriana; Animais; Cafeína/farmacologia; Ésteres; Ácidos Graxos/farmacologia; Antagonistas GABAérgicos/farmacologia; Glicerol/farmacologia; Hipnóticos e Sedativos/farmacologia; Hipnóticos e Sedativos/uso terapêutico; Camundongos; Pentobarbital; Extratos Vegetais/farmacologia; Extratos Vegetais/uso terapêutico; Sono; Distúrbios do Início e da Manutenção do Sono/induzido quimicamente; Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico; Espectrometria de Massas em Tandem

Palavras-chave

Capsaicin; Diazepam; Distribution; Kessyl glycol; Kessyl glycol 2-acetate; Kessyl glycol 8-acetate; Kessyl glycol diacetate; Sedative; Umbelliferone; Valeriana fauriei root; Î³-aminobutyric acid receptor type a

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Texto completo: 1 Base de dados: MEDLINE Medicinas Complementares: Homeopatia Assunto principal: Valeriana / Distúrbios do Início e da Manutenção do Sono Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2022 Tipo de documento: Article

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