Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage.

Tian, Wen-Jing; Zhou, Mi; Qiu, Da-Ren; Chen, Jun-Jie; Liu, Xiang-Zhong; Li, Jing-Dian; Lin, Ting; Wang, Guang-Hui; Chen, Haifeng

Tian, Wen-Jing; Zhou, Mi; Qiu, Da-Ren; Chen, Jun-Jie; Liu, Xiang-Zhong; Li, Jing-Dian; Lin, Ting; Wang, Guang-Hui; Chen, Haifeng.

Afiliação

Tian WJ; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, People's Republic of China. Electronic address: tianwj@xmu.edu.cn.
Zhou M; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, People's Republic of China.
Qiu DR; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, People's Republic of China.
Chen JJ; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, People's Republic of China.
Liu XZ; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, People's Republic of China.
Li JD; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, People's Republic of China.
Lin T; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, People's Republic of China.
Wang GH; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, People's Republic of China.
Chen H; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, People's Republic of China. Electronic address: haifeng@xmu.edu.cn.

Bioorg Chem ; 128: 106088, 2022 11.

Article em En | MEDLINE | ID: mdl-36007479

Assuntos

Hypericum; Apoptose; Pontos de Checagem do Ciclo Celular; Humanos; Hypericum/química; Células MCF-7; Estrutura Molecular; Estresse Oxidativo; Floroglucinol/química

Palavras-chave

Cytotoxicity; Hypericum elodeoides; Phloroglucinol

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hypericum Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article