Arctium lappa leaves based on network pharmacology and experimental validation attenuate atherosclerosis by targeting the AMPK-mediated PPARG/LXR&#945; pathway.

Wang, Mengmeng; Cui, Bingdi; Gong, Man; Liu, Qiuyan; Zhuo, Xingxu; Lv, Jiangnan; Yang, Lianhe; Liu, Xiaoqian; Wang, Zhimin; Dai, Liping

Arctium lappa leaves based on network pharmacology and experimental validation attenuate atherosclerosis by targeting the AMPK-mediated PPARG/LXRα pathway.

Wang, Mengmeng; Cui, Bingdi; Gong, Man; Liu, Qiuyan; Zhuo, Xingxu; Lv, Jiangnan; Yang, Lianhe; Liu, Xiaoqian; Wang, Zhimin; Dai, Liping.

Afiliação

Wang M; Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Cui B; Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Gong M; Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Liu Q; The Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Zhuo X; Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Lv J; Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Yang L; Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Liu X; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Wang Z; Henan University of Chinese Medicine, Zhengzhou, Henan, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Engineering Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Zhengzhou, Henan
Dai L; Henan University of Chinese Medicine, Zhengzhou, Henan, China; Engineering Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Zhengzhou, Henan 450046, China. Electronic address: liping_dai@hactcm.edu.cn.

Biomed Pharmacother ; 153: 113503, 2022 Sep.

Article em En | MEDLINE | ID: mdl-36076592

Assuntos

Arctium; Aterosclerose; Proteínas Quinases Ativadas por AMP/efeitos dos fármacos; Proteínas Quinases Ativadas por AMP/metabolismo; Transportador 1 de Cassete de Ligação de ATP/metabolismo; Animais; Arctium/química; Aterosclerose/tratamento farmacológico; Aterosclerose/metabolismo; Colesterol/metabolismo; Medicamentos de Ervas Chinesas/farmacologia; Medicamentos de Ervas Chinesas/uso terapêutico; Receptores X do Fígado/efeitos dos fármacos; Receptores X do Fígado/metabolismo; Simulação de Acoplamento Molecular; Farmacologia em Rede/métodos; PPAR gama/efeitos dos fármacos; PPAR gama/metabolismo; Ratos; Sirtuína 1/metabolismo

Palavras-chave

AMPK; Arctium lappa leaves; Atherosclerosis; Cardiovascular disease; Cholesterol efflux; PPARG/LXRα

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Arctium / Aterosclerose Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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