Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue.

Ng, Jerome P L; Han, Yu; Yang, Li Jun; Birkholtz, Lyn-Marie; Coertzen, Dina; Wong, Ho Ning; Haynes, Richard K; Coghi, Paolo; Wong, Vincent Kam Wai

Ng, Jerome P L; Han, Yu; Yang, Li Jun; Birkholtz, Lyn-Marie; Coertzen, Dina; Wong, Ho Ning; Haynes, Richard K; Coghi, Paolo; Wong, Vincent Kam Wai.

Afiliação

Ng JPL; Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Han Y; Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Yang LJ; Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Birkholtz LM; Department of Biochemistry, Genetics and Microbiology, University of Pretoria Institute Malaria for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa.
Coertzen D; Department of Biochemistry, Genetics and Microbiology, University of Pretoria Institute Malaria for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa.
Wong HN; Centre of Excellence for Pharmaceutical Sciences, School of Health Sciences, North-West University, Potchefstroom, South Africa.
Haynes RK; Centre of Excellence for Pharmaceutical Sciences, School of Health Sciences, North-West University, Potchefstroom, South Africa.
Coghi P; School of Pharmacy, Macau University of Science and Technology, Macau, China.
Wong VKW; Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.

Front Pharmacol ; 13: 988748, 2022.

Article em En | MEDLINE | ID: mdl-36120293

Palavras-chave

artemisinin; artemisone; cancer; celastrol; malaria; redox drug; synergism

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China