Integrated strategy of RNA-sequencing and network pharmacology for exploring the protective mechanism of Shen-Shi-Jiang-Zhuo formula in rat with non-alcoholic fatty liver disease.

Xu, Zheng; Wu, Fan-Wei; Niu, Xuan; Lu, Xiao-Peng; Li, Yan-Rong; Zhang, Shu-Ting; Ou, Jun-Zhao; Wang, Xue-Mei

Xu, Zheng; Wu, Fan-Wei; Niu, Xuan; Lu, Xiao-Peng; Li, Yan-Rong; Zhang, Shu-Ting; Ou, Jun-Zhao; Wang, Xue-Mei.

Afiliação

Xu Z; Liu Pai Chinese Medical Center, The Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
Wu FW; School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Niu X; Liu Pai Chinese Medical Center, The Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
Lu XP; Liu Pai Chinese Medical Center, The Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
Li YR; Liu Pai Chinese Medical Center, The Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
Zhang ST; Liu Pai Chinese Medical Center, The Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
Ou JZ; Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wang XM; Liu Pai Chinese Medical Center, The Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.

Pharm Biol ; 60(1): 1819-1838, 2022 Dec.

Article em En | MEDLINE | ID: mdl-36124995

Assuntos

Hepatopatia Gordurosa não Alcoólica; Alanina Transaminase; Animais; Aspartato Aminotransferases; Colesterol; Dieta Hiperlipídica; Farmacologia em Rede; Hepatopatia Gordurosa não Alcoólica/patologia; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; RNA/uso terapêutico; Ratos; Ratos Sprague-Dawley; Triglicerídeos; gama-Glutamiltransferase/uso terapêutico

Palavras-chave

Hepatic lipid accumulation; PI3K/AKT pathway; Traditional Chinese medicine; hepatic fibrosis; liver function damage

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies Idioma: En Revista: Pharm Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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