Steppogenin suppresses tumor growth and sprouting angiogenesis through inhibition of HIF-1&#945; in tumors and DLL4 activity in the endothelium.

Cha, Sora; Kim, Hyoung-Geun; Jang, Hyeonha; Lee, Jihoon; Chao, Tang; Baek, Nam-In; Song, Im-Sook; Lee, You Mie

Steppogenin suppresses tumor growth and sprouting angiogenesis through inhibition of HIF-1α in tumors and DLL4 activity in the endothelium.

Cha, Sora; Kim, Hyoung-Geun; Jang, Hyeonha; Lee, Jihoon; Chao, Tang; Baek, Nam-In; Song, Im-Sook; Lee, You Mie.

Afiliação

Cha S; Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook Nati
Kim HG; Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Kyung Hee University, Yongin 17104, Korea.
Jang H; Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook Nati
Lee J; Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook Nati
Chao T; Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook Nati
Baek NI; Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Kyung Hee University, Yongin 17104, Korea.
Song IS; Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook Nati
Lee YM; Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook Nati

Phytomedicine ; 108: 154513, 2023 Jan.

Article em En | MEDLINE | ID: mdl-36332389

Assuntos

Neoplasias; Fator A de Crescimento do Endotélio Vascular; Humanos; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Proteínas de Ligação ao Cálcio/metabolismo; Hipóxia Celular; Linhagem Celular Tumoral; Células Endoteliais/metabolismo; Endotélio/metabolismo; Endotélio/patologia; Células HEK293; Hipóxia; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Neoplasias/patologia; Neovascularização Patológica/tratamento farmacológico; Neovascularização Patológica/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

Angiogenesis; HIF-1α, DLL4; Hypoxia; Solid tumor; Steppogenin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator A de Crescimento do Endotélio Vascular / Neoplasias Idioma: En Revista: Phytomedicine Ano de publicação: 2023 Tipo de documento: Article

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