Efficacy of a Probiotic and Herbal Supplement in Models of Lung Inflammation.
Microorganisms
; 10(11)2022 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-36363728
ABSTRACT
BACKGROUND:
Gut microbiome dysbiosis is associated with lung disease through the gut-lung axis. Abundant proteobacteria increase MMP-9 and contribute to tissue proteolysis followed by neutrophil recruitment, lung tissue injury, and perpetuation of chronic lung disease. We sought to determine if a scientifically formulated probiotic and herbal supplement could attenuate neutrophilic inflammation and improve lung structure and function in models of lung inflammation.METHODS:
For in vitro experiments, epithelial cells exposed to proteobacteria were treated with resB-a blend of three probiotic Lactobacillus strains and turmeric, holy basil, and vasaka herbal extracts. For in vivo experimentation, mice exposed to pulmonary proteobacteria-derived lipopolysaccharide were treated by gavage with resB.RESULTS:
In vitro, the bacterial and herbal components of resB decreased activity of the MMP-9 pathway. Mice exposed to LPS and pre- and post-treated with resB had decreased neutrophil recruitment and inflammatory biomarkers in bronchoalveolar lavage fluid, serum, and lung tissue compared to untreated mice.CONCLUSIONS:
This study describes the mechanisms and efficacy of probiotic and herbal blend in pre-clinical models of lung injury and inflammation.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Microorganisms
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos