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Simvastatin therapy in higher dosages deteriorates bone quality: Consistent evidence from population-wide patient data and interventional mouse studies.
Leutner, Michael; Butylina, Maria; Matzhold, Caspar; Klimek, Peter; Cuhaj, Carina; Bellach, Luise; Baumgartner-Parzer, Sabina; Reiter, Birgit; Preindl, Karin; Kautzky, Alexander; Stimpfl, Thomas; Thurner, Stefan; Pietschmann, Peter; Fürnsinn, Clemens; Kautzky-Willer, Alexandra.
Afiliação
  • Leutner M; Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
  • Butylina M; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
  • Matzhold C; Section for Science of Complex Systems, CeMSIIS, Medical University of Vienna, Spitalgasse 23, A-1090, Austria; Complexity Science Hub Vienna, Josefstaedter Straße 39, 1080 Vienna, Austria.
  • Klimek P; Section for Science of Complex Systems, CeMSIIS, Medical University of Vienna, Spitalgasse 23, A-1090, Austria; Complexity Science Hub Vienna, Josefstaedter Straße 39, 1080 Vienna, Austria.
  • Cuhaj C; Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
  • Bellach L; Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
  • Baumgartner-Parzer S; Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
  • Reiter B; Joint Metabolome Facility, University and Medical University of Vienna, Vienna, Austria.
  • Preindl K; Joint Metabolome Facility, University and Medical University of Vienna, Vienna, Austria.
  • Kautzky A; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
  • Stimpfl T; Joint Metabolome Facility, University and Medical University of Vienna, Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
  • Thurner S; Section for Science of Complex Systems, CeMSIIS, Medical University of Vienna, Spitalgasse 23, A-1090, Austria; Complexity Science Hub Vienna, Josefstaedter Straße 39, 1080 Vienna, Austria; Santa Fe Institute, Santa Fe, NM 85701, USA.
  • Pietschmann P; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
  • Fürnsinn C; Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Electronic address: clemens.fuernsinn@meduniwien.ac.at.
  • Kautzky-Willer A; Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria; Gender Institute, A-3571 Gars am Kamp, Austria. Electronic address: alexandra.kautzky-willer@meduniwien.ac.at.
Biomed Pharmacother ; 158: 114089, 2023 Feb.
Article em En | MEDLINE | ID: mdl-36538862
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose / Inibidores de Hidroximetilglutaril-CoA Redutases Tipo de estudo: Etiology_studies / Observational_studies Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Áustria
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose / Inibidores de Hidroximetilglutaril-CoA Redutases Tipo de estudo: Etiology_studies / Observational_studies Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Áustria