Cucurbitane-type triterpenoids from the fruits of Citrullus colocynthis.
Fitoterapia
; 165: 105405, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-36572119
ABSTRACT
A phytochemical investigation of the fruits of Citrullus colocynthis resulted in the isolation of 21 structurally diverse cucurbitane triterpenoids, including 9 previously undescribed ones, colocynins A-I (1-9). Their absolute configurations were elucidated by means of quantum chemical electronic circular dichroism (ECD) calculations, CD exciton chirality method, and single-crystal X-ray crystallography. Colocynins A-C (1-3) represent the first examples of nonanorcucurbitane-type triterpenoids. An anti-acetylcholinesterase activity assay showed that 6, 10, 13, 18, and 20 exhibited inhibitory activities, with IC50 values ranging from 5.0 to 21.7 µM. In addition, 18 and 21 showed significant cytotoxicity against PACA, A431, and HepG2 cells, with IC50 values ranging from 0.042 to 0.60 and 3.6-14.4 µM, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Citrullus colocynthis
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2023
Tipo de documento:
Article