Alpinetin inhibits neuroinflammation and neuronal apoptosis via targeting the JAK2/STAT3 signaling pathway in spinal cord injury.

Xiao, Shining; Zhang, Yu; Liu, Zihao; Li, Anan; Tong, Weilai; Xiong, Xu; Nie, Jiangbo; Zhong, Nanshan; Zhu, Guoqing; Liu, Jiaming; Liu, Zhili

Xiao, Shining; Zhang, Yu; Liu, Zihao; Li, Anan; Tong, Weilai; Xiong, Xu; Nie, Jiangbo; Zhong, Nanshan; Zhu, Guoqing; Liu, Jiaming; Liu, Zhili.

Afiliação

Xiao S; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Zhang Y; Institute of Spine and Spinal Cord, Nanchang University, Nanchang, China.
Liu Z; Medical Innovation Center, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Li A; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Tong W; Institute of Spine and Spinal Cord, Nanchang University, Nanchang, China.
Xiong X; Medical Innovation Center, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Nie J; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Zhong N; Institute of Spine and Spinal Cord, Nanchang University, Nanchang, China.
Zhu G; Medical Innovation Center, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Liu J; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Liu Z; Institute of Spine and Spinal Cord, Nanchang University, Nanchang, China.

CNS Neurosci Ther ; 29(4): 1094-1108, 2023 04.

Article em En | MEDLINE | ID: mdl-36627822

Assuntos

Flavonas; Doenças Neuroinflamatórias; Traumatismos da Medula Espinal; Animais; Ratos; Apoptose/efeitos dos fármacos; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Janus Quinase 2/efeitos dos fármacos; Janus Quinase 2/metabolismo; Lipopolissacarídeos; Microglia; Doenças Neuroinflamatórias/tratamento farmacológico; Ratos Sprague-Dawley; Transdução de Sinais; Medula Espinal/metabolismo; Traumatismos da Medula Espinal/tratamento farmacológico; Traumatismos da Medula Espinal/metabolismo; Flavonas/farmacologia; Flavonas/uso terapêutico; Fator de Transcrição STAT3/efeitos dos fármacos; Fator de Transcrição STAT3/metabolismo

Palavras-chave

Alpinetin; JAK2/STAT3 pathway; neurinflammation; neuronal apoptosis; spinal cord injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Flavonas / Doenças Neuroinflamatórias Tipo de estudo: Prognostic_studies Idioma: En Revista: CNS Neurosci Ther Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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