Total flavones of Rhododendron induce the transformation of A1/A2 astrocytes via promoting the release of CBS-produced H<sub>2</sub>S.

Yin, Xiaojiao; Liu, Bo; Ding, Yanyu; Li, Xueyan; Sheng, Ju; Guo, Yan; Chen, Zhiwu; Wen, Jiyue

Total flavones of Rhododendron induce the transformation of A1/A2 astrocytes via promoting the release of CBS-produced H₂S.

Yin, Xiaojiao; Liu, Bo; Ding, Yanyu; Li, Xueyan; Sheng, Ju; Guo, Yan; Chen, Zhiwu; Wen, Jiyue.

Afiliação

Yin X; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, NO.81 Meishan Road, Hefei 230032, China.
Liu B; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, NO.81 Meishan Road, Hefei 230032, China.
Ding Y; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, NO.81 Meishan Road, Hefei 230032, China.
Li X; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, NO.81 Meishan Road, Hefei 230032, China.
Sheng J; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, NO.81 Meishan Road, Hefei 230032, China.
Guo Y; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, NO.81 Meishan Road, Hefei 230032, China. Electronic address: 772845430@qq.com.
Chen Z; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, NO.81 Meishan Road, Hefei 230032, China. Electronic address: chpharmzw@163.com.
Wen J; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, NO.81 Meishan Road, Hefei 230032, China. Electronic address: wenjiyue139@aliyun.com.

Phytomedicine ; 111: 154666, 2023 Mar.

Article em En | MEDLINE | ID: mdl-36701996

Assuntos

Isquemia Encefálica; Flavonas; Rhododendron; Animais; Camundongos; Astrócitos; Isquemia Encefálica/tratamento farmacológico; Isquemia Encefálica/metabolismo; Cistationina beta-Sintase/metabolismo; Cistationina beta-Sintase/farmacologia; Flavonas/farmacologia; Oxigênio/metabolismo; Rhododendron/metabolismo

Palavras-chave

Astrocyte; CBS-produced H(2)S; RhoA-ROCK signaling pathway; Subtype; Total flavones of Rhododendron

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Rhododendron / Flavonas Tipo de estudo: Prognostic_studies Idioma: En Revista: Phytomedicine Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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