Integerrima A-E, phenylethanoid glycosides from the stem of Callicarpa integerrima.
J Nat Med
; 77(3): 496-507, 2023 Jun.
Article
em En
| MEDLINE
| ID: mdl-37002508
Five new phenylethanoid glycosides integerrima A-E (1-5) were isolated from the stem of Callicarpa integerrima for the first time. Their structures were elucidated by extensive spectroscopic analyses. In addition, cytotoxicity, anti-adipogenic and antioxidant activities were evaluated. All the phenylethanoid glycosides would be nontoxic to the normal human hepatocytes LO-2 and pre-adipocytes 3T3-L1 cell lines, significantly promote the proliferation of normal hepatocytes, thus displaying the potential for hepatoprotective. Integerrima A (1), C (3) and D (4) exhibited selectively moderate cytotoxic activity against the hepatoma cell lines Bel-7402, with the IC50 value at 72.66, 80.43 and 84.88 µmol/L, respectively. Moreover, integerrima D (4) had significant activities on reducing lipid droplet formation, with the inhibition rate of 48.02% on the concentration of 200 µg/mL. Finally, the result of FRAP assays exhibited remarkable antioxidant activity in integerrima E (5), which was close to the positive control ascorbic acid with the concentration of 100 µg/mL.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Callicarpa
/
Antineoplásicos
Idioma:
En
Revista:
J Nat Med
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China