Cochlear Implants in Deaf Patients with Novel TMPRSS3 Gene Mutation.
Altern Ther Health Med
; 29(5): 102-106, 2023 Jul.
Article
em En
| MEDLINE
| ID: mdl-37023310
ABSTRACT
Objective:
To investigate the effect of cochlear implants in deaf patients with TMPRSS3 gene pathogenic variations.Methods:
Variations of deafness genes were detected in 2 patients with profound hearing loss. Both received unilateral cochlear implantation. Hearing and speech abilities were evaluated and analyzed before and 3 and 6 months after surgery. The analysis included post-surgery evaluation of auditory behavior (Categories of Performance [CAP]) and Speech Intelligibility Rating (SIR).Results:
In the 2 patients, 3 pathogenic single nucleotide variations (SNVs) of TMPRSS3 gene and a large deletion in 21q22.3 were detected. The CAP and SIR grades increased with the recovery time.Conclusion:
Cochlear implants have a good effect in patients with TMPRSS3 gene mutation deafness. Preoperative gene testing has a certain reference significance for the prognosis in patients with the deafness gene mutation.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Percepção da Fala
/
Implantes Cocleares
/
Implante Coclear
/
Surdez
Idioma:
En
Revista:
Altern Ther Health Med
Ano de publicação:
2023
Tipo de documento:
Article