Amphetamine withdrawal: a behavioral evaluation.
Life Sci
; 38(17): 1617-23, 1986 Apr 28.
Article
em En
| MEDLINE
| ID: mdl-3702594
ABSTRACT
The effects of withdrawal from long-term amphetamine treatment of intracranial self-stimulation, forced swim-induced immobility, shuttle escape performance, acoustic startle and locomotor activity were evaluated. Mice implanted with stimulating electrodes in the lateral hypothalamus demonstrated stable and reliable rates of self-stimulation responding. After exposure to a chronic schedule of amphetamine treatment response rates were severely depressed. In addition to modifying intracranial self-stimulation responding, amphetamine withdrawal increased the duration of immobility in a forced-swim situation. Although chronic amphetamine exposure induced pronounced behavioral changes in the intracranial self-stimulation and forced swim tasks, drug withdrawal had little effect on shuttle escape performance, acoustic startle and locomotor activity. Based on these findings it was suggested that the development of post-amphetamine depression in the self-stimulation and forced swim paradigms was not related to variations in motoric or arousal mechanisms resulting from amphetamine withdrawal, but rather involved drug-induced changes in motivational processes.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Abstinência a Substâncias
/
Dextroanfetamina
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1986
Tipo de documento:
Article