Hypothermia or hyperthermia, which is associated with patient outcomes in critically ill children with sepsis? -A retrospective study.
BMJ Open
; 13(4): e067716, 2023 04 17.
Article
em En
| MEDLINE
| ID: mdl-37068899
ABSTRACT
OBJECTIVES:
In the early stage of sepsis, identifying high-risk paediatric patients with a poor prognosis and providing timely and adequate treatment are critical. This study aimed to evaluate the effect of average body temperature within 24 hours of admission on the short-term prognosis of paediatric patients with sepsis.DESIGN:
A retrospective cohort study.SETTING:
A single-centre, tertiary care hospital in China, containing patient data from 2010 to 2018.PARTICIPANTS:
1144 patients with sepsis were included. INTERVENTION None. PRIMARY AND SECONDARY OUTCOMEMEASURES:
The main outcome measure was in-hospital mortality, which was defined as death from any cause during hospitalisation. The secondary outcome was the length of hospital stay.RESULTS:
The LOWESS method showed a roughly 'U'-shaped relationship between body temperature on the first day and in-hospital mortality. Multivariate logistic regression showed that severe hypothermia (OR 14.72, 95% CI 4.84 to 44.75), mild hypothermia (OR 3.71, 95% CI 1.26 to 10.90), mild hyperthermia (OR 3.41, 95% CI 1.17 to 9.90) and severe hyperthermia (OR 5.15, 95% CI 1.84 to 14.43) were independent risk factors for in-hospital mortality. Compared with other variables, the Wald χ2 value of temperature on the first day minus the degree of freedom was the highest.CONCLUSIONS:
Whether hypothermic or hyperthermic, the more abnormal the temperature on the first day is, the higher the risk of in-hospital death in children with sepsis.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Hipertermia Induzida
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Hipotermia
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
BMJ Open
Ano de publicação:
2023
Tipo de documento:
Article