Your browser doesn't support javascript.
loading
Acylated iridoid glucoside and xanthones from Canscora lucidissima: Their structures and ferroptosis inhibitory activity.
Tanaka, Naonobu; Shibata, Ikko; Tasaki, Yusuke; Yoshino, Yuki; Tsuji, Daisuke; Lu, Feng-Lai; Yan, Xiao-Jie; Yang, Xue-Rong; Itoh, Kohji; Akagi, Reiko; Li, Dian-Peng; Kashiwada, Yoshiki.
Afiliação
  • Tanaka N; Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan. Electronic address: ntanak@tokushima-u.ac.jp.
  • Shibata I; Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
  • Tasaki Y; Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
  • Yoshino Y; Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
  • Tsuji D; Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan; Faculty of Pharmacy, Yasuda Women's University, Hiroshima 731-0153, Japan.
  • Lu FL; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, China.
  • Yan XJ; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, China.
  • Yang XR; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, China. Electronic address: yxr@gxib.cn.
  • Itoh K; Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
  • Akagi R; Faculty of Pharmacy, Yasuda Women's University, Hiroshima 731-0153, Japan.
  • Li DP; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, China.
  • Kashiwada Y; Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
Fitoterapia ; 168: 105539, 2023 Jul.
Article em En | MEDLINE | ID: mdl-37178810
Phytochemical study on the whole plants of a Gentianaceous medicinal plant, Canscora lucidissima, gave one new acylated iridoid glucoside, canscorin A (1), and two new xanthone glycosides (2 and 3) together with 17 known compounds including five xanthones, eight xanthone glycosides, two benzophenone glucosides, caffeic acid, and loganic acid. Canscorin A (1) was assigned as a loganic acid derivative having a hydroxyterephthalic acid moiety by spectroscopic analysis together with chemical evidence, while 2 and 3 were elucidated to be a rutinosylxanthone and a glucosylxanthone, respectively. The absolute configurations of the sugar moieties of 2 and 3 were determined by HPLC analysis. The isolated compounds were evaluated for their inhibitory activities against erastin-induced ferroptosis on human hepatoma Hep3B cells and LPS-stimulated IL-1ß production from murine microglial cells.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gentianaceae / Xantonas / Ferroptose Idioma: En Revista: Fitoterapia Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gentianaceae / Xantonas / Ferroptose Idioma: En Revista: Fitoterapia Ano de publicação: 2023 Tipo de documento: Article