Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPAR&#945;/CD36 pathway.

Chen, Suwen; Sun, Shangwen; Feng, Yanan; Li, Xiu; Yin, Guoliang; Liang, Pengpeng; Yu, Wenfei; Meng, Decheng; Zhang, Xin; Liu, Hongshuai; Zhang, Fengxia

Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway.

Chen, Suwen; Sun, Shangwen; Feng, Yanan; Li, Xiu; Yin, Guoliang; Liang, Pengpeng; Yu, Wenfei; Meng, Decheng; Zhang, Xin; Liu, Hongshuai; Zhang, Fengxia.

Afiliação

Chen S; Shandong University of Traditional Chinese Medicine, Jinan, 250013, China.
Sun S; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Feng Y; Shandong University of Traditional Chinese Medicine, Jinan, 250013, China.
Li X; Department of Endocrinology, Affiliated Linshu County People's Hospital, Linyi, 276799, China.
Yin G; Shandong University of Traditional Chinese Medicine, Jinan, 250013, China.
Liang P; Shandong University of Traditional Chinese Medicine, Jinan, 250013, China.
Yu W; Shandong University of Traditional Chinese Medicine, Jinan, 250013, China.
Meng D; Shandong University of Traditional Chinese Medicine, Jinan, 250013, China.
Zhang X; Shandong University of Traditional Chinese Medicine, Jinan, 250013, China.
Liu H; Shandong University of Traditional Chinese Medicine, Jinan, 250013, China.
Zhang F; Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250013, China. Electronic address: fxzhang0987@163.com.

Eur J Pharmacol ; 952: 175808, 2023 Aug 05.

Article em En | MEDLINE | ID: mdl-37263401

Assuntos

Diosgenina; Hepatopatia Gordurosa não Alcoólica; Animais; Ratos; Ácidos Graxos/metabolismo; Ácidos Graxos não Esterificados/farmacologia; Fígado; Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico; Hepatopatia Gordurosa não Alcoólica/metabolismo; PPAR alfa/genética; PPAR alfa/metabolismo; Ratos Sprague-Dawley; Proteína de Ligação a Elemento Regulador de Esterol 1/genética; Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo; Diosgenina/uso terapêutico

Palavras-chave

Diosgenin; Farnesoid X receptor (FXR); Fatty acid uptake; Fatty acid ß-oxidation; Nonalcoholic fatty liver disease (NAFLD); de novo lipogenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diosgenina / Hepatopatia Gordurosa não Alcoólica Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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