Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors.
Curr Opin Pharmacol
; 71: 102382, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-37307655
ABSTRACT
Gonadotropin-releasing hormone (GnRH) neurons are the final output pathway for the brain control of reproduction. The activity of this neuronal population, mainly located at the preoptic area of the hypothalamus, is controlled by a plethora of metabolic signals. However, it has been documented that most of these signal impact on GnRH neurons through indirect neuronal circuits, Kiss1, proopiomelanocortin, and neuropeptide Y/agouti-related peptide neurons being some of the most prominent mediators. In this context, compelling evidence has been gathered in recent years on the role of a large range of neuropeptides and energy sensors in the regulation of GnRH neuronal activity through both direct and indirect mechanisms. The present review summarizes some of the most prominent recent advances in our understanding of the peripheral factors and central mechanisms involved in the metabolic control of GnRH neurons.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeos
/
Hormônio Liberador de Gonadotropina
Idioma:
En
Revista:
Curr Opin Pharmacol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Espanha