Peniciriols A and B, two new citrinin derivatives from an endophytic fungus Penicillum citrinum TJNZ-27.
Fitoterapia
; 169: 105572, 2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-37315718
ABSTRACT
Two undescribed citrinin derivatives, named peniciriols A-B (1-2), together with six known compounds were isolated from endophytic fungus Penicillum citrinum TJNZ-27. The structures of two new compounds were well established by the detail interpretation of NMR and HRESIMS data as well as ECD measurement powered by molecular calculation. Among them, compound 1 shared an unprecedented dimerized citrinin skeleton with the formation of an intriguing 9H-xanthene ring system, whereas compound 2 possess a highly substituted phenylacetic acid skeleton, which was rarely-occurring in natural secondary metabolites. Moreover, these novel compounds were tested for cytotoxic and antibacterial activities, whereas these novel compounds did not exhibit any noticeable cytotoxic or antibacterial activities.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Penicillium
/
Citrinina
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2023
Tipo de documento:
Article