Effect of acupuncture on regulating IL-17, TNF-É and AQPs in Sjögren's syndrome.
Oral Dis
; 30(1): 50-62, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37518974
ABSTRACT
AIM:
The aim of the study was to observe the effect of acupuncture on regulating interleukin (IL)-17, tumor necrosis factor (TNF)-É, and aquaporins (AQPs) in Sjögren's syndrome (SS) on patients and on non-obese diabetic (NOD) models.METHODS:
Levels of anti-AQP 1, 5, 8, and 9 antibodies, IL-17, and TNF-É in the serum of SS patients were compared prior and following 20 acupuncture treatment visits during 8 weeks. While in murine model, five groups were divided to receive interventions for 4 weeks, including control, model, acupuncture, isoflurane, and hydroxychloroquine. The submaxillofacial gland index, histology, immunohistochemistry of AQP1, 5, salivary flow, together with IL-17, and TNF-É expression in peripheral blood were compared among the groups.RESULTS:
Acupuncture reduced IL-17, TNF-É, and immunoglobin A levels, and numeric analog scale of dryness in 14 patients with SS (p < 0.05). The salivary flow was increased, and the water intake decreased in NOD mice receiving acupuncture treatments. IL-17 and TNF-É levels in peripheral serum were down-regulated (p < 0.05) and AQP1, 5 expression in the submandibular glands up-regulated in mice.CONCLUSION:
The effect on relieving xerostomia with acupuncture may be achieved by up-regulating the expression of AQP1. AQP5, down-regulating levels of IL-17 and TNF-É, and a decrease in inflammation of glands.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapêuticos e Terapias MTCI:
Terapias_manuales
Assunto principal:
Síndrome de Sjogren
/
Terapia por Acupuntura
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Oral Dis
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China