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Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial.
Serrano, José C E; Castro-Boqué, Eva; García-Carrasco, Alicia; Morán-Valero, María Inés; González-Hedström, Daniel; Bermúdez-López, Marcelino; Valdivielso, José Manuel; Espinel, Alberto E; Portero-Otín, Manuel.
Afiliação
  • Serrano JCE; NUTREN-Nutrigenomics, Department of Experimental Medicine, University of Lleida, 25198 Lleida, Spain.
  • Castro-Boqué E; Vascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida, IRBLleida, 25198 Lleida, Spain.
  • García-Carrasco A; Vascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida, IRBLleida, 25198 Lleida, Spain.
  • Morán-Valero MI; Pharmactive Biotech S.L.U., 28049 Madrid, Spain.
  • González-Hedström D; Pharmactive Biotech S.L.U., 28049 Madrid, Spain.
  • Bermúdez-López M; Vascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida, IRBLleida, 25198 Lleida, Spain.
  • Valdivielso JM; Vascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida, IRBLleida, 25198 Lleida, Spain.
  • Espinel AE; Pharmactive Biotech S.L.U., 28049 Madrid, Spain.
  • Portero-Otín M; NUTREN-Nutrigenomics, Department of Experimental Medicine, University of Lleida, 25198 Lleida, Spain.
Nutrients ; 15(17)2023 Aug 23.
Article em En | MEDLINE | ID: mdl-37686723
ABSTRACT
The use of garlic (Allium sativum) for treating arterial hypertension has been recognized as effective for several decades. However, tolerance to treatment is low, and several technological modifications have been developed to improve its tolerability, such as the aging process at controlled temperature and humidity. This study aims to validate the antihypertensive effects of an optimized extract of aged black garlic with low doses of s-allyl-cysteine (SAC) in a Grade I hypertensive population with drug treatment. A randomized, triple-blind, placebo-controlled parallel trial was developed, where a daily supplementation with 0.25 mg/day of SAC for 12 weeks was performed. A reduction in systolic and diastolic blood pressure of 1.8 mmHg (0.7 to 4.1 95% CI) and 1.5 mmHg (0.3 to 3.0 95% CI), respectively, was observed. Similarly, an increase in blood nitric oxide (10.3 µM, 1.1 to 19.5 95% CI) and antioxidant capacity (7 × 10-3 µM TE/min, (1.2 to 13 × 10-3 95% CI) and a reduction in uric acid levels (-0.3 mg/dL, -0.5 to -0.001 95% CI) and ACE activity (-9.3 U/L; -18.4 to -0.4 95% CI) were observed. No changes in endothelial function and inflammatory cytokines were observed. It was concluded that low-dose SAC supplementation in an optimized black-garlic extract allows for an extra-significant reduction in blood pressure in a Grade I hypertensive population receiving drug treatment.
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Texto completo: 1 Base de dados: MEDLINE Medicinas Complementares: Homeopatia Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas / Plantas_medicinales Assunto principal: Produtos Biológicos / Alho / Hipertensão Tipo de estudo: Clinical_trials Idioma: En Revista: Nutrients Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Base de dados: MEDLINE Medicinas Complementares: Homeopatia Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas / Plantas_medicinales Assunto principal: Produtos Biológicos / Alho / Hipertensão Tipo de estudo: Clinical_trials Idioma: En Revista: Nutrients Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha