A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-&#954;B pathway and activation Nrf2 pathway in macrophages.

Shen, Xiaofei; Chen, Hongqing; Zhang, Hai; Luo, Liuling; Wen, Tian; Liu, Lu; Hu, Qiongying; Wang, Lun

A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages.

Shen, Xiaofei; Chen, Hongqing; Zhang, Hai; Luo, Liuling; Wen, Tian; Liu, Lu; Hu, Qiongying; Wang, Lun.

Afiliação

Shen X; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chen H; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China; College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhang H; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Luo L; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Wen T; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China; College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Liu L; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Hu Q; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China; College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Wang L; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China. Electronic address: wanglun@cib.ac.cn.

Int Immunopharmacol ; 124(Pt B): 110965, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37741124

Assuntos

Lesão Pulmonar Aguda; Sesquiterpenos; Animais; Camundongos; Lesão Pulmonar Aguda/induzido quimicamente; Lesão Pulmonar Aguda/tratamento farmacológico; Lesão Pulmonar Aguda/metabolismo; Anti-Inflamatórios/farmacologia; Quinase I-kappa B/metabolismo; Interleucina-6/metabolismo; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Lactonas/farmacologia; Lactonas/uso terapêutico; Lactonas/metabolismo; Lipopolissacarídeos/farmacologia; Macrófagos; Simulação de Acoplamento Molecular; Fator 2 Relacionado a NF-E2/metabolismo; NF-kappa B/metabolismo; Sesquiterpenos/farmacologia; Sesquiterpenos/uso terapêutico; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Acute lung injury; Anti-inflammatory activity; IKKα/ß-NF-κB pathway; Isolinderalactone; Keap1-Nrf2 pathway; Macrophages

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Sesquiterpenos / Lesão Pulmonar Aguda Idioma: En Revista: Int Immunopharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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