Spatiotemporal molecular dynamics of the developing human thalamus.
Science
; 382(6667): eadf9941, 2023 10 13.
Article
em En
| MEDLINE
| ID: mdl-37824646
ABSTRACT
The thalamus plays a central coordinating role in the brain. Thalamic neurons are organized into spatially distinct nuclei, but the molecular architecture of thalamic development is poorly understood, especially in humans. To begin to delineate the molecular trajectories of cell fate specification and organization in the developing human thalamus, we used single-cell and multiplexed spatial transcriptomics. We show that molecularly defined thalamic neurons differentiate in the second trimester of human development and that these neurons organize into spatially and molecularly distinct nuclei. We identified major subtypes of glutamatergic neuron subtypes that are differentially enriched in anatomically distinct nuclei and six subtypes of γ-aminobutyric acid-mediated (GABAergic) neurons that are shared and distinct across thalamic nuclei.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tálamo
/
Neurogênese
/
Neurônios GABAérgicos
Idioma:
En
Revista:
Science
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos