Subchronic toxicity of iron-selenium nanoparticles on oxidative stress response, histopathological, and nuclear damage in amphibian larvae Rana saharica.
Environ Sci Pollut Res Int
; 30(52): 112321-112335, 2023 Nov.
Article
em En
| MEDLINE
| ID: mdl-37831248
ABSTRACT
In this work, we evaluated the subchronic toxicity of FeSe nanoparticles (NPs) in tadpoles of Rana saharica. Tadpoles were exposed for 1-3 weeks to FeSe NPs at 5 mg/L and 100 mg/L rates. Parameters of oxidative stress were measured in whole larvae, and the micronucleus test was performed on circulating blood erythrocytes. We noted a disturbance of the detoxification systems. Enzymatic and non-enzymatic data showed that exposure to FeSe NPs involved a highly significant depletion of GSH, a significant increase in GST activity, and a lipid peroxidation associated with a highly significant increase in MDA. We also noted a neurotoxic effect characterized by a significant inhibition of AChE activity. A micronucleus test showed concentration-dependent DNA damage. This research reveals that these trace elements, in their nanoform, can cause significant neurotoxicity, histopathologic degeneration, cellular and metabolic activity, and genotoxic consequences in Rana larvae.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Selênio
/
Nanopartículas
Idioma:
En
Revista:
Environ Sci Pollut Res Int
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Argélia