Paeonol reduces microbial metabolite &#945;-hydroxyisobutyric acid to alleviate the ROS/TXNIP/NLRP3 pathway-mediated endothelial inflammation in atherosclerosis mice.

Liu, Yarong; Wu, Hongfei; Wang, Tian; Shi, Xiaoyan; He, Hai; Huang, Hanwen; Yang, Yulong; Dai, Min

Paeonol reduces microbial metabolite α-hydroxyisobutyric acid to alleviate the ROS/TXNIP/NLRP3 pathway-mediated endothelial inflammation in atherosclerosis mice.

Liu, Yarong; Wu, Hongfei; Wang, Tian; Shi, Xiaoyan; He, Hai; Huang, Hanwen; Yang, Yulong; Dai, Min.

Afiliação

Liu Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Hefei 230012, China.
Wu H; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Hefei 230012, China.
Wang T; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
Shi X; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
He H; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
Huang H; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
Yang Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
Dai M; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Hefei 230012, China. Electronic address: daiminliao@163.com.

Chin J Nat Med ; 21(10): 759-774, 2023 Oct.

Article em En | MEDLINE | ID: mdl-37879794

Assuntos

Aterosclerose; Proteína 3 que Contém Domínio de Pirina da Família NLR; Animais; Camundongos; Aterosclerose/tratamento farmacológico; Dieta Hiperlipídica; Células Endoteliais; Inflamação/tratamento farmacológico; Camundongos Endogâmicos C57BL; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Espécies Reativas de Oxigênio

Palavras-chave

Atherosclerosis; Gut microbiota; Paeonol; Vascular endothelial inflammation; α-Hydroxyisobutyric acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose / Proteína 3 que Contém Domínio de Pirina da Família NLR Idioma: En Revista: Chin J Nat Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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