Diverse terpenoid glycosides with in vitro cytotoxicity from Glechoma longituba.
Phytochemistry
; 217: 113923, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37963510
ABSTRACT
Terpenoids are the largest class of all known natural products, possessing structural diversity and numerous biological activities. Ten previously undescribed terpenoid glycosides, glechlongsides A-J (1-10), were isolated from the ethanol extract of the whole plant of Glechoma longituba, including diterpenoid glycoside and pentacyclic triterpenoid saponin. The structures of these compounds were characterized by extensive analysis of 1D and 2D NMR as well as HRESIMS spectra. In addition, glechlongsides F-I (6-9) exhibited weak cytotoxicity against human cancer cell lines BGC-823, Be1, HCT-8, A2780, and A549 with IC50 values ranging from 3.77 to 30.95 µM, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Lamiaceae
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China