Activation of PXR causes drug interactions with Paxlovid in transgenic mice.

Lei, Saifei; Guo, Alice; Lu, Jie; Qi, Qian; Devanathan, Aaron S; Zhu, Junjie; Ma, Xiaochao

Lei, Saifei; Guo, Alice; Lu, Jie; Qi, Qian; Devanathan, Aaron S; Zhu, Junjie; Ma, Xiaochao.

Afiliação

Lei S; Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Guo A; School of Nursing, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lu J; Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Qi Q; Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Devanathan AS; Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Zhu J; Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Ma X; Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Acta Pharm Sin B ; 13(11): 4502-4510, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37969744

Palavras-chave

CYP3A4/5; Drug/herbdrug interactions; Nirmatrelvir; Paxlovid; Pregnane X receptor; Rhynchophylline; Rifampicin; Ritonavir

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos