Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis.
Br J Nutr
; 131(9): 1473-1487, 2024 May 14.
Article
em En
| MEDLINE
| ID: mdl-38221822
ABSTRACT
Vitamin D is a vital indicator of musculoskeletal health, as it plays an important role through the regulation of bone and mineral metabolism. This meta-analysis was performed to investigate the effects of vitamin D supplementation/fortification on bone turnover markers in women. All human randomised clinical trials reported changes in bone resorption markers (serum C-terminal telopeptide of type-I collagen (sCTX) and urinary type I collagen cross-linked N-telopeptide (uNTX)) or bone formation factors (osteocalcin (OC), bone alkaline phosphatase (BALP) and procollagen type-1 intact N-terminal propeptide (P1NP)) following vitamin D administration in women (aged ≥ 18 years) were considered. Mean differences (MD) and their respective 95 % CI were calculated based on fixed or random effects models according to the heterogeneity status. Subgroup analyses, meta-regression models, sensitivity analysis, risk of bias, publication bias and the quality of the included studies were also evaluated. We found that vitamin D supplementation had considerable effect on sCTX (MD -0·038, n 22) and OC (MD -0·610, n 24) with high heterogeneity and uNTX (MD -8·188, n 6) without heterogeneity. Our results showed that age, sample size, dose, duration, baseline vitamin D level, study region and quality of studies might be sources of heterogeneity in this meta-analysis. Subgroup analysis also revealed significant reductions in P1NP level in dose less than 600 µg/d and larger study sample size (>100 participants). Moreover, no significant change was found in BALP level. Vitamin D supplementation/fortification significantly reduced bone resorption markers in women. However, results were inconsistent for bone formation markers.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vitamina D
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Biomarcadores
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Remodelação Óssea
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Suplementos Nutricionais
Tipo de estudo:
Clinical_trials
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Prognostic_studies
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Systematic_reviews
Idioma:
En
Revista:
Br J Nutr
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Irã