New indolequinazoline alkaloids from the fruits of Tetradium ruticarpum.

Li, Mu; Chen, Xin-Lin; Yu, Zhan-Peng; Li, Ya-Lin; Hong, Li-Hong; Cai, Yu-Xing; Kong, Ling-Yi; Luo, Jian-Guang

Li, Mu; Chen, Xin-Lin; Yu, Zhan-Peng; Li, Ya-Lin; Hong, Li-Hong; Cai, Yu-Xing; Kong, Ling-Yi; Luo, Jian-Guang.

Afiliação

Li M; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Chen XL; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Yu ZP; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Li YL; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Hong LH; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Cai YX; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Kong LY; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.. Electronic address: cpu_lykong@126.com.
Luo JG; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.. Electronic address: luojg@cpu.edu.cn.

Fitoterapia ; 174: 105843, 2024 Apr.

Article em En | MEDLINE | ID: mdl-38301937

ABSTRACT

ABSTRACT

In this research, five new indolequinazoline alkaloids (1-5), along with six known indolequinazoline alkaloids (6-11) were obtained from the fruits of Tetradium ruticarpum. Their structures were elucidated through comprehensive spectroscopic data of 1D and 2D NMR, HRESIMS and ECD spectra. Additionally, all isolates were assayed for their SIRT1 inhibitory activities in vitro and compounds 2, 7, 10 and 11 exhibited activities with IC50 values ranged from 43.16 to 118.35 µM.

Assuntos

Alcaloides; Evodia; Evodia/química; Frutas/química; Estrutura Molecular; Alcaloides/análise; Espectroscopia de Ressonância Magnética

Palavras-chave

Indolequinazoline alkaloids; Rutaceae; SIRT1 inhibitory activity; Tetradium ruticarpum

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Evodia / Alcaloides Idioma: En Revista: Fitoterapia Ano de publicação: 2024 Tipo de documento: Article