Revolutionizing gastric cancer treatment: The potential of immunotherapy.
World J Gastroenterol
; 30(4): 286-289, 2024 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-38313231
ABSTRACT
Gastric cancer, a prevalent malignancy worldwide, ranks sixth in terms of frequency and third in fatality, causing over a million new cases and 769000 annual deaths. Predominant in Eastern Europe and Eastern Asia, risk factors include family medical history, dietary habits, tobacco use, Helicobacter pylori, and Epstein-Barr virus infections. Unfortunately, gastric cancer is often diagnosed at an advanced stage, leading to a grim prognosis, with a 5-year overall survival rate below 5%. Surgical intervention, particularly with D2 Lymphadenectomy, is the mainstay for early-stage cases but offers limited success. For advanced cases, the National Comprehensive Cancer Network recommends chemotherapy, radiation, and targeted therapy. Emerging immunotherapy presents promise, especially for unresectable or metastatic cases, with strategies like immune checkpoint inhi-bitors, tumor vaccines, adoptive immunotherapy, and nonspecific immunomodulators. In this Editorial, with regards to the article "Advances and key focus areas in gastric cancer immunotherapy A comprehensive scientometric and clinical trial review", we address the advances in the field of immunotherapy in gastric cancer and its future prospects.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Infecções por Vírus Epstein-Barr
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
World J Gastroenterol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Grécia